0001193125-17-118704 Sample Contracts

FIRST SUPPLEMENTAL INDENTURE
First Supplemental Indenture • April 10th, 2017 • Keryx Biopharmaceuticals Inc • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of April 10, 2017, among KERYX BIOPHARMACEUTICALS, INC., a Delaware corporation (the “Company”), THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association, as Trustee under the Indenture referred to below (in such capacity, the “Trustee”), and the Holder signatory hereto.

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