0001193125-17-219883 Sample Contracts

FORM OF SECURITIES SUBSCRIPTION AGREEMENT
Securities Subscription Agreement • June 30th, 2017 • ProQR Therapeutics N.V. • Pharmaceutical preparations • New York

The undersigned (the “Investor”) hereby confirms and agrees with ProQR Therapeutics N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (the “Company”) as follows:

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ProQR Therapeutics N.V. 1,200,000 Ordinary Shares PLACEMENT AGENCY AGREEMENT Dated: June 28, 2017
Placement Agency Agreement • June 30th, 2017 • ProQR Therapeutics N.V. • Pharmaceutical preparations • New York

ProQR Therapeutics N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (the “Company”), hereby appoints Leerink Partners LLC as its placement agent (the “Placement Agent”) in connection with the proposed sale to certain investors on the date hereof (the “Direct Offering”) of 1,200,000 ordinary shares, nominal value €0.04 per ordinary share, of the Company (“Ordinary Shares”). The aforesaid 1,200,000 Ordinary Shares to be placed by the Placement Agent are herein called, the “Securities.”

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