0001193125-17-286909 Sample Contracts

DEPOSIT AGREEMENT by and among NUCANA PLC and CITIBANK, N.A., as Depositary, and ALL HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED HEREUNDER Dated as of [DATE], 2017
Deposit Agreement • September 18th, 2017 • NuCana PLC • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT, dated as of [DATE], 2017, by and among (i) NuCana plc, a public limited company incorporated under the laws of England and Wales and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America (“Citibank”) acting in its capacity as depositary, and any successor depositary hereunder (Citibank in such capacity, the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

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NuCana plc [●] American Depositary Shares Representing An Aggregate of [●] Ordinary Shares Underwriting Agreement
Letter Agreement • September 18th, 2017 • NuCana PLC • Pharmaceutical preparations • New York

The ADSs will be evidenced by American Depositary Receipts (“ADRs”) issued pursuant to that certain Deposit Agreement dated [●], 2017 (the “Deposit Agreement”), by and among the Company, Citibank, N.A. as depositary (the “Depositary”), and all holders and beneficial owners of ADSs issued thereunder. The Company shall, following subscription by the Underwriters of the Offered Securities pursuant to this Agreement, deposit, on behalf of the Underwriters, the Shares being delivered in the form of the Offered Securities with Citibank, N.A., London Branch as custodian (the “Custodian”) for the Depositary, which shall deliver the Offered Securities to the Representatives for the account of the several Underwriters for subsequent delivery to the other several Underwriters or the investors, as the case may be.

Conformed Copy as amended pursuant to a Variation Agreement between the parties dated 15th March 2012. ASSIGNMENT, LICENCE AND COLLABORATION AGREEMENT between NUCANA BIOMED LIMITED and CARDIFF PROTIDES LIMITED Dated: 13th October 2009
Sub-Licence Agreement • September 18th, 2017 • NuCana PLC • Pharmaceutical preparations • England

NUCANA BIOMED LIMITED, a company incorporated in England under the Companies Acts (Registered No. 03308778) and having its registered office at Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey GU15 3PU (“BioMed”);

Research, Collaboration and Licence Agreement THIS AGREEMENT is made this 21st day of August 2009 BETWEEN:
Licence Agreement • September 18th, 2017 • NuCana PLC • Pharmaceutical preparations
REGISTRATION RIGHTS AGREEMENT dated as of among NUCANA PLC and THE INVESTORS PARTY HERETO
Registration Rights Agreement • September 18th, 2017 • NuCana PLC • Pharmaceutical preparations • Delaware

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), is made as of the [ ] day of [ ], 2017, by and among NuCana plc, a company incorporated under the laws of England and Wales (the “Company”), each of the shareholders listed on Schedule A hereto (the “Major Investors”) and each of the shareholders listed on Schedule B hereto (the “Original Investors”) who become party hereto prior to the Effectiveness Date (as defined below). The Major Investors and the Original Investors are collectively referred to herein as the “Investors” and each is referred to herein as an “Investor”.

DEED OF INDEMNITY
NuCana PLC • September 18th, 2017 • Pharmaceutical preparations
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