0001193125-17-312671 Sample Contracts

DEPOSIT AGREEMENT by and among NIGHTSTAR THERAPEUTICS PLC And CITIBANK, N.A., as Depositary, and THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED HEREUNDER Dated as of September 27, 2017
Deposit Agreement • October 18th, 2017 • Nightstar Therapeutics PLC • Biological products, (no disgnostic substances) • New York

DEPOSIT AGREEMENT, dated as of September 27, 2017, by and among (i) NIGHTSTAR THERAPEUTICS PLC, a public limited company incorporated under the laws of England and Wales, and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America (“Citibank”) acting in its capacity as depositary, and any successor depositary hereunder (Citibank in such capacity, the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

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