0001193125-18-051252 Sample Contracts

AERPIO PHARMACEUTICALS, INC. Issuer AND AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee INDENTURE Dated as of [●] Senior Debt Securities
Indenture • February 21st, 2018 • Aerpio Pharmaceuticals, Inc. • Pharmaceutical preparations • New York
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AERPIO PHARMACEUTICALS, INC. Shares of Common Stock (par value $0.0001 per share) Controlled Equity OfferingSM Sales Agreement
Sales Agreement • February 21st, 2018 • Aerpio Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Aerpio Pharmaceuticals, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (the “Agent”), as follows:

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