0001193125-18-300266 Sample Contracts

KARYOPHARM THERAPEUTICS INC., as Issuer AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of October 16, 2018 3.00% Convertible Senior Notes due 2025
Indenture • October 16th, 2018 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • New York

INDENTURE dated as of October 16, 2018 (this “Indenture”, as more fully set forth in Section 1.01) between KARYOPHARM THERAPEUTICS INC., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and WILMINGTON TRUST, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01).

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