0001193125-18-350381 Sample Contracts

TAKEDA PHARMACEUTICAL COMPANY LIMITED AND THE BANK OF NEW YORK MELLON As Depositary AND OWNERS AND HOLDERS OF AMERICAN DEPOSITARY SHARES Amended and Restated Deposit Agreement Dated as of , 2018
Deposit Agreement • December 17th, 2018 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations • New York

AMENDED AND RESTATED DEPOSIT AGREEMENT dated as of , 2018 among TAKEDA PHARMACEUTICAL COMPANY LIMITED, a joint-stock corporation incorporated under the laws of Japan (herein called the Company), THE BANK OF NEW YORK MELLON, a New York banking corporation (herein called the Depositary), and all Owners (as hereinafter defined) and Holders (as hereinafter defined) from time to time of American Depositary Shares (as hereinafter defined) issued hereunder.

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REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 17th, 2018 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations • New York

This REGISTRATION RIGHTS AGREEMENT dated November 26, 2018 (this “Agreement”) is entered into by and among Takeda Pharmaceutical Company Limited, a joint stock corporation organized under the laws of Japan (the “Company”), and J.P. Morgan Securities LLC (“J.P. Morgan”), SMBC Nikko Securities America, Inc., Morgan Stanley MUFG Securities Co., Ltd., Mizuho Securities USA LLC and Merrill Lynch, Pierce, Fenner & Smith Incorporated as representatives of the several initial purchasers named in Schedule A to the Purchase Agreement (as defined below) (the “Initial Purchasers”).

Loan Agreement
Loan Agreement • December 17th, 2018 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations

TAKEDA PHARMACEUTICAL COMPANY LIMITED, a corporation duly incorporated and existing under the Laws of the Borrower’s Country having its principal office at 1-1, Doshomachi 4-chome, Chuo-ku, Osaka, Japan (the “Borrower”);

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