0001193125-19-155301 Sample Contracts

February 12, 2019 Stephen Tulipano Stoneham, MA 02180
Non-Competition Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • Delaware

On behalf of Stoke Therapeutics, Inc. (the “Company”), this letter agreement (the “Agreement”) sets forth the terms and conditions of your appointment as the Company’s Chief Financial Officer, effective as of March 18, 2019 (the “Employment Date”).

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Edward Kaye, M.D. [ADDRESS]
Confidentiality and Non-Competition Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • Delaware

On behalf of Stoke Therapeutics, Inc. (the “Company”), this letter agreement (the “Agreement”) sets forth the terms and conditions of your appointment as the Company’s Chief Executive Officer, effective as of October 17, 2017 (the “Employment Date”).

September 8, 2017 Barry Ticho, M.D., Ph.D. Newton, MA
Employment Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

On behalf of Stoke Therapeutics, Inc. (the “Company”), this letter agreement (the “Agreement”) sets forth the terms and conditions of your appointment as the Company’s Chief Medical Officer, effective as of October 2, 2017 (the “Employment Date”).

CONSULTING AGREEMENT
Consulting Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations

This Agreement is made as of October 24, 2014 between ASOthera Pharmaceuticals, Inc. (the “Company”) and Adrian Krainer, PhD (the “Consultant”), an employee of the Cold Spring Harbor Laboratory (“CSHL”). The Company is engaged in scientific research relating to the development of antisense-based drugs, therapies, diagnostic and research tools, products, services and intellectual property (the “Field”). The Consultant has experience in the Field, and the Company seeks to benefit from the Consultant’s expertise by retaining the Consultant as a consultant. The Consultant wishes to perform consulting services in the Field for the Company. Accordingly, the Company and the Consultant agree as follows:

November 20, 2015 Huw M. Nash, Ph.D. Lexington, MA 02421
Confidentiality Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • New York

On behalf of ASOthera Pharmaceuticals, Inc. (the “Company”), this letter agreement (the “Agreement”) sets forth the terms and conditions of your appointment as the Chief Executive Officer of the Company, effective as of October 24, 2014 (the “Employment Date”).

LICENSE AGREEMENT BETWEEN UNIVERSITY OF SOUTHAMPTON AND ASOTHERA PHARMACEUTICALS, INC.
License Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • England and Wales

This License Agreement (“Agreement”) is made effective as of the date of last signature as written below (the “Effective Date”) by and between University of Southampton, whose administrative offices are at University Road, Highfield, Southampton, SO17 1BJ (“University”) and ASOthera Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware (“ASOthera”), having an office at 3 Preston Court, Suite 102, Bedford, MA 01730.

LICENSE AGREEMENT BETWEEN COLD SPRING HARBOR LABORATORY AND ASOTHERA PHARMACEUTICALS, INC.
Restricted Stock Purchase Agreement • May 23rd, 2019 • Stoke Therapeutics, Inc. • Pharmaceutical preparations • New York

This License Agreement (“Agreement”) is made effective as of July 31, 2015 (the “Effective Date”) by and between Cold Spring Harbor Laboratory, a nonprofit New York State education corporation (“CSHL”) having an office at One Bungtown Road, Cold Spring Harbor, New York 11724 and ASOthera Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware (“ASOthera”), having an office at One Bungtown Road, Cold Spring Harbor, New York 11724.

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