0001193125-19-161286 Sample Contracts

Aptose Biosciences Inc. 10,000,000 Common Shares (no par value per share) Underwriting Agreement
Underwriting Agreement • May 30th, 2019 • Aptose Biosciences Inc. • Biological products, (no disgnostic substances) • New York

Aptose Biosciences Inc., a company incorporated under the Canada Business Corporations Act (the “Company”), proposes to issue and sell to the several underwriters named in Schedule A (the “Underwriters”) an aggregate of 10,000,000 common shares, no par value per share (the “Shares”). The 10,000,000 Shares to be sold by the Company are called the “Firm Shares.” In addition, the Company has granted to the Underwriters an option to purchase up to an additional 1,500,000 Shares as provided in Section 2. The additional 1,500,000 Shares that may be sold by the Company pursuant to such option are collectively called the “Optional Shares.” The Firm Shares and, if and to the extent such option is exercised, the Optional Shares, are collectively called the “Offered Shares.” RBC Capital Markets, LLC (“RBC”) and Canaccord Genuity LLC (“Canaccord”) have agreed to act as representatives of the several Underwriters (in such capacity, the “Representatives”) in connection with the offering and sale of

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