0001193125-20-080680 Sample Contracts

AKCEA THERAPEUTICS, INC.
Akcea Therapeutics, Inc. • March 20th, 2020 • Pharmaceutical preparations • Massachusetts
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AKCEA THERAPEUTICS, INC. GLOBAL OPTION AGREEMENT (INCENTIVE STOCK OPTION OR NON-STATUTORY STOCK OPTION)
Global Option Agreement • March 20th, 2020 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • Delaware

Pursuant to your Option Grant Notice (“Grant Notice”) and a Global Option Agreement, including all appendices thereto (each, a “Prior Option Agreement”), Akcea Therapeutics, Inc. (the “Company”) granted you an option under its 2015 Equity Incentive Plan (the “Plan”) to purchase the number of shares of the Company’s Common Stock (the “Option”) indicated in your Grant Notice at the exercise price indicated in your Grant Notice and as set forth in TABLE 1. This Global Option Agreement (this “Agreement”) terminates, supersedes and replaces each Prior Option Agreement solely with respect to the Options identified in TABLE 1 below.

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