0001193125-20-186859 Sample Contracts

KARUNA THERAPEUTICS, INC. Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 202[•] Subordinated Debt Securities
Indenture • July 2nd, 2020 • Karuna Therapeutics, Inc. • Pharmaceutical preparations • New York
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KARUNA THERAPEUTICS, INC. Up to $150,000,000 of Common Stock ($0.0001 par value) Equity Distribution Agreement
Equity Distribution Agreement • July 2nd, 2020 • Karuna Therapeutics, Inc. • Pharmaceutical preparations • New York

Karuna Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Goldman Sachs & Co. LLC (the “Manager”) as follows. To the extent there is a single Manager, all references to the “Managers” and the “Designated Manager” as used herein shall refer only to Goldman Sachs & Co. LLC, and the terms “Managers” shall mean either the singular or the plural as the context requires.

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