0001193125-21-224404 Sample Contracts

FIRST AMENDMENT TO TERM LOAN AGREEMENT
Term Loan Agreement • July 26th, 2021 • Strongbridge Biopharma PLC • Pharmaceutical preparations • New York

This FIRST AMENDMENT TO TERM LOAN AGREEMENT, dated as of July 23, 2021 (this “Amendment”), is entered into by and among Strongbridge U.S. Inc., a Delaware corporation (the “Borrower”), Strongbridge Biopharma plc, a public limited company incorporated under the laws of Ireland (the “Parent Guarantor”), each Lender party hereto designated as a “Lender” on its signature page hereto (collectively constituting the Majority Lenders (as defined in the Existing Credit Agreement)), Avenue Venture Opportunities Fund, L.P., a Delaware limited partnership, as administrative agent and collateral agent for the Lenders under the Existing Credit Agreement (in such capacities, collectively, the “Administrative Agent”). Capitalized terms used but not otherwise defined in this Amendment have the same meanings as specified in the Existing Credit Agreement.

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Lock-Up Agreement
Strongbridge Biopharma PLC • July 26th, 2021 • Pharmaceutical preparations • New York
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