0001193125-21-310422 Sample Contracts

John M. Maraganore, Ph.D., at the address on file with Alnylam Pharmaceuticals, Inc. Dear John:
Alnylam Pharmaceuticals, Inc. • October 28th, 2021 • Pharmaceutical preparations

In connection with your retirement as Chief Executive Officer of Alnylam Pharmaceuticals, Inc. (the “Company”), this letter agreement (the “Letter Agreement”) sets forth the terms of your retirement and your transition to providing consulting services to the Company. If you agree with the terms described in this Letter Agreement, which include a general release, please sign in the space provided below and return it to me. You must also reaffirm the release and restrictive covenants in this Letter Agreement following your Transition Date and the end of your Consulting Period as described in Paragraph No. 14(b) (collectively, your “Reaffirmations”).

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