0001193125-21-333790 Sample Contracts

THERMO FISHER SCIENTIFIC (FINANCE I) B.V., as Issuer THERMO FISHER SCIENTIFIC INC., as Guarantor AND THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. as Trustee FOURTH SUPPLEMENTAL INDENTURE Dated as of November 18, 2021 Floating Rate Senior Notes due 2023
Fourth Supplemental Indenture • November 18th, 2021 • Thermo Fisher Scientific Inc. • Measuring & controlling devices, nec • New York

THIS FOURTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”) is dated as of November 18, 2021 among THERMO FISHER SCIENTIFIC (FINANCE I) B.V., a private limited liability company (besloten vennootschap met beperkte aansprakelijkheid) incorporated under the laws of the Netherlands, with its corporate seat (statutaire zetel) in Breda, the Netherlands, and its registered office at Takkebijsters 1, 4817 BL Breda, the Netherlands, registered with the Dutch Trade Register of the Chamber of Commerce under number 66428319 (the “Company”), THERMO FISHER SCIENTIFIC INC., a Delaware corporation (the “Guarantor”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association, as trustee (the “Trustee”).

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