0001193125-22-000260 Sample Contracts

Amylyx Pharmaceuticals, Inc. Common Stock Underwriting Agreement
Underwriting Agreement • January 3rd, 2022 • Amylyx Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Amylyx Pharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated in this agreement (this “Agreement”), to issue and sell to the Underwriters named in Schedule I hereto (the “Underwriters”) an aggregate of [•] shares (the “Firm Shares”) and, at the election of the Underwriters, up to [•] additional shares (the “Optional Shares”) of common stock, par value $0.0001 per share (“Stock”) of the Company (the Firm Shares and the Optional Shares that the Underwriters elect to purchase pursuant to Section 2 hereof being collectively called the “Shares”).

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EMPLOYMENT AGREEMENT
Employment Agreement • January 3rd, 2022 • Amylyx Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

This Employment Agreement (“Agreement”) is made between Amylyx Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and James Frates (the “Executive”) and is effective as of the closing of the Company’s first underwritten public offering of its equity securities pursuant to an effective registration statement under the Securities Act of 1933, as amended (the “Effective Date”). Except with respect to the Restrictive Covenants Agreement and the Equity Documents (each as defined below) and subject to Section 12, this Agreement supersedes in all respects all prior agreements between the Executive and the Company regarding the subject matter herein, including without limitation (i) the employment agreement between the Executive and the Company dated January 25, 2021 (the “Prior Agreement”), and (ii) any other offer letter, employment agreement or severance agreement.

EMPLOYMENT AGREEMENT
Employment Agreement • January 3rd, 2022 • Amylyx Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into as of the 18th day of March 2019 (the “Effective Date”), by and between PATRICK D. YERAMIAN, M.D. of 1815 SW 22nd Avenue Circle, Boca Raton, FL. 33486 (the “Employee”) and AMYLYX PHARMACEUTICALS, INC., a Delaware corporation duly organized under law and having a usual place of business at 43 Thorndike Street, Cambridge, MA 02141 (the “Company”).

EMPLOYMENT AGREEMENT
Employment Agreement • January 3rd, 2022 • Amylyx Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into as of the 1st day of August, 2015 (the “Effective Date”), by and between JUSTIN KLEE of 169 Monsignor O’Brien Highway, Apt. 403, Cambridge, MA 02141 (the “Employee”) and AMYLYX PHARMACEUTICALS, INC., a Delaware corporation duly organized under law and having a usual place of business 210 Broadway #201, Cambridge, MA 02139 (the “Company”).

EMPLOYMENT AGREEMENT
Employment Agreement • January 3rd, 2022 • Amylyx Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into as of the 25th day of January, 2021 (the “Effective Date”), by and between JAMES FRATES of 471 Grove Street, Needham, MA 02492 (the “Employee”) and AMYLYX PHARMACEUTICALS, INC., a Delaware corporation duly organized under law and having a usual place of business at 43 Thorndike Street, Cambridge, MA 02141 (the “Company”).

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