0001193125-24-023462 Sample Contracts

INDEMNIFICATION AGREEMENT

Indemnification Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  Indemnification Agreement
• Filed
  February 5th, 2024
• Company
  Spyre Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

This Indemnification Agreement (this “Agreement”) is entered into as of by and between Spyre Therapeutics, Inc., a Delaware corporation (the “Company”), and (the “Indemnitee”) and shall be deemed effective upon the earliest date that the Indemnitee is duly elected or appointed as a director or officer of the Company.

February 1, 2024 Cameron Turtle Re: Amendment to Amended and Restated Employment Letter Agreement Dear Cameron:

Employment Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations • Washington

• Contract Type
  Employment Agreement
• Filed
  February 5th, 2024
• Company
  Spyre Therapeutics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Washington

This letter, effective as of the date first set forth above (this “Amendment”), amends that certain amended and restated employment letter agreement between you and Spyre Therapeutics, Inc. (f/k/a Aeglea BioTherapeutics, Inc.) (the “Company”) dated November 22, 2023 (the “Agreement”).