AMENDMENT NO. 1 TO DEPOSIT AGREEMENT by and among NUCANA PLC AND CITIBANK, N.A., as Depositary, AND ALL HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED HEREUNDER Dated as of April 16, 2024Deposit Agreement • August 15th, 2024 • NuCana PLC • Pharmaceutical preparations • New York
Contract Type FiledAugust 15th, 2024 Company Industry JurisdictionAMENDMENT NO. 1 TO DEPOSIT AGREEMENT, dated as of April 16, 2024 (“Amendment No. 1”), by and among (i) NuCana plc, a public limited company incorporated under the laws of the England and Wales, and its successors (the “Company”), (ii) Citibank, N.A., a national banking association organized under the laws of the United States of America acting in its capacity as depositary, and any successor depositary hereunder (the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares outstanding under the Deposit Agreement (as hereinafter defined).