0001193125-24-233296 Sample Contracts

Upstream Bio, Inc. [•] Shares of Common Stock, par value $0.001 per share Underwriting Agreement
Underwriting Agreement • October 7th, 2024 • Upstream Bio, Inc. • Pharmaceutical preparations • New York
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UPSTREAM BIO, INC. FORM OF EMPLOYEE DIRECTOR / OFFICER INDEMNIFICATION AGREEMENT
Indemnification Agreement • October 7th, 2024 • Upstream Bio, Inc. • Pharmaceutical preparations • Delaware

This Indemnification Agreement (“Agreement”) is made as of [•], 2024, by and between Upstream Bio, Inc., a Delaware corporation (the “Company”), and [Name] (“Indemnitee”).

March 27, 2024
Employment Agreement • October 7th, 2024 • Upstream Bio, Inc. • Pharmaceutical preparations
March 11, 2024 Michael Gray Re: Employment Offer Dear Mike:
Employment Agreement • October 7th, 2024 • Upstream Bio, Inc. • Pharmaceutical preparations
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