Exhibit (a)Deposit Agreement • November 14th, 2014 • Citibank,N.A./ADR • Pharmaceutical preparations • New York
Contract Type FiledNovember 14th, 2014 Company Industry JurisdictionAMENDED AND RESTATED DEPOSIT AGREEMENT, dated as of May 23, 2011 (this “Deposit Agreement”), among SHIRE plc (the “Company”) and its successors, CITIBANK, N.A., as successor depositary hereunder (the “Depositary”), and all Holders and Beneficial Owners from time to time of American Depositary Receipts (“ADRs”) issued hereunder evidencing American Depositary Shares (“ADSs”) representing deposited Shares (as defined below).