0001193805-16-003723 Sample Contracts

AMENDED AND RESTATED DEPOSIT AGREEMENT
Deposit Agreement • August 12th, 2016 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

AMENDED AND RESTATED DEPOSIT AGREEMENT, dated as of November 4, 2011, by and among (i) Amarin Corporation plc, a company organized under the laws of England and Wales, and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America acting in its capacity as depositary, and any successor depositary hereunder (the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

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To: Citibank, N.A. – ADR Depositary 388 Greenwich Street, 14th Floor New York, NY 10013 Attention: Depositary Receipt Department Re: Corsicanto Limited – Exchangeable Senior Notes Due 2032 Amarin Corporation plc – ADSs (CUSIP No.: 023111206)
Deposit Agreement • August 12th, 2016 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

References is made to the Amended and Restated Deposit Agreement, dated as of November 4, 2011, by and among Amarin Corporation plc, a company organized under the laws of England and Wales (the "Company"), Citibank, N.A., as depositary (the "Depositary"), and all Holders and Beneficial Owners of American Depositary Shares ("ADSs") issued thereunder (the "Deposit Agreement"). Terms used, but not otherwise defined, herein shall have the meaning ascribed to them in the Deposit Agreement.

To: Citibank, N.A. – ADR Depositary 388 Greenwich Street, 14th Floor New York, NY 10013 Attention: Depositary Receipt Department Re: Amarin Corporation plc – Exchange Letter Agreement ADSs (CUSIP No.: 023111206) & Restricted ADSs (CUSIP No.: 0231119H2)
Exchange Letter Agreement • August 12th, 2016 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

This Resale Certification is being provided in connection with our request to the Depositary to transfer the Restricted ADSs specified below (CUSIP No.: 0231119H2) registered in the name of the undersigned or the undersigned's designee in the form of freely transferable ADSs in connection with our sale of such ADSs in a transaction exempt from registration under the Securities Act or covered by a Registration Statement (the "Sale").

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