0001193805-16-004278 Sample Contracts

Contract
JPMorgan Chase Bank, N.A. - ADR Depositary • November 17th, 2016 • American depositary receipts • New York

AMENDMENT NO. 1, dated as of November , 2016 (the "Amendment"), to the Third Amended and Restated Deposit Agreement dated as of February 27, 2014 (the "Deposit Agreement") among Roche Holding Ltd (the "Company"), incorporated under the laws of Switzerland, JPMorgan Chase Bank, N.A., as depositary (the "Depositary"), and all holders from time to time of American depositary receipts ("ADRs") issued thereunder.

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