0001193805-17-001026 Sample Contracts

Contract
Deposit Agreement • June 7th, 2017 • JPMorgan Chase Bank, N.A. - ADR Depositary • American depositary receipts • New York

AMENDMENT NO. 1, dated as of , 2017 (the "Amendment"), to the Amended and Restated Deposit Agreement dated as of May 25, 2004 (the "Deposit Agreement") among Eisai Co., Ltd., incorporated under the laws of Japan (the "Company"), JPMorgan Chase Bank, N.A., as depositary (the "Depositary"), and all holders from time to time of American depositary receipts ("ADRs") issued thereunder.

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