0001193805-19-001038 Sample Contracts

Contract
Deposit Agreement • October 8th, 2019 • JPMorgan Chase Bank, N.A. - ADR Depositary • American depositary receipts • New York

AMENDMENT NO. 1, dated as of October , 2019 (the "Amendment"), to the Deposit Agreement dated as of November 19, 2018 (the "Deposit Agreement") among Tiziana Life Sciences plc, incorporated under the laws of England and Wales (the "Company"), JPMorgan Chase Bank, N.A., as depositary (the "Depositary"), and all holders from time to time of American depositary receipts ("ADRs") issued thereunder.

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