0001206774-10-002228 Sample Contracts

Amendment to the Non-Exclusive License and Material Transfer Agreement dated as of March 30, 2007
Regeneron Pharmaceuticals Inc • October 28th, 2010 • Pharmaceutical preparations • New York

This Amendment (“Amendment”), dated as of July 28, 2010 (the “Amendment Effective Date”), is by and between Astellas Pharma Inc. (“Company”), a Japanese company with a principal place of business located at 2-3-11 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan and Regeneron Pharmaceuticals, Inc. (“Regeneron”), a New York corporation with its principal place of business at 777 Old Saw Mill River Road, Tarrytown, New York 10591.

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