0001279569-11-001380 Sample Contracts

SECOND SUPPLEMENTAL INDENTURE
Second Supplemental Indenture • December 5th, 2011 • Lorus Therapeutics Inc • Biological products, (no disgnostic substances) • Ontario

WHEREAS by a warrant indenture (hereinafter called the “Warrant Indenture”) made as of the 4th day of October, 2010 and supplemented by a first supplemental indenture dated as of the 18th day of October, 2010 (the “First Supplemental Indenture”) between the Company and the Warrant Agent, provision was made for the issue by the Company of the Warrants (as defined in the Warrant Indenture);

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