0001279569-13-000248 Sample Contracts

EXECUTION VERSION
Settlement Agreement • March 4th, 2013 • Cardiome Pharma Corp • Pharmaceutical preparations

This Settlement Agreement (this “Settlement Agreement”) is entered into as of December 10, 2012 (the “Settlement Date”), by and among Cardiome Pharma Corp., a Canadian corporation with offices at 6190 Agronomy Rd., Suite 405, Vancouver, B.C., Canada, V6T 1Z3 (“CARDIOME”), and Merck Sharp & Dohme Corp. (as successor in interest to the entity formerly known as Merck & Co., Inc.), a corporation organized under the laws of New Jersey with offices at One Merck Drive, Whitehouse Station, NJ 08889-0100, U.S.A. (“Merck & Co.”).

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Amendment #2 to Settlement Agreement Regarding the Merck Cardiome Line of Credit
Settlement Agreement • March 4th, 2013 • Cardiome Pharma Corp • Pharmaceutical preparations

This Amendment #2 (“Amendment #2”) is effective as of February 28, 2013 by and among Cardiome Pharma Corp., a Canadian corporation with offices at 6190 Agronomy Rd., Suite 405, Vancouver, B.C., Canada, V6T 1Z3 ("CARDIOME"), and Merck Sharp & Dohme Corp. (as successor in interest to the entity formerly known as Merck & Co., Inc.), a corporation organized under the laws of New Jersey with offices at One Merck Drive, Whitehouse Station, NJ 08889-0100, U.S.A. ("Merck & Co.").

Amendment #1 to the Settlement Agreement dated December 10, 2012, Regarding the Merck Cardiome Line of Credit
Settlement Agreement • March 4th, 2013 • Cardiome Pharma Corp • Pharmaceutical preparations

This Amendment #1 (“Amendment”) is effective as of December 31, 2012 by and among Cardiome Pharma Corp., a Canadian corporation with offices at 6190 Agronomy Rd., Suite 405, Vancouver, B.C., Canada, V6T 1Z3 ("CARDIOME"), and Merck Sharp & Dohme Corp. (as successor in interest to the entity formerly known as Merck & Co., Inc.), a corporation organized under the laws of New Jersey with offices at One Merck Drive, Whitehouse Station, NJ 08889-0100, U.S.A. ("Merck & Co.").

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