0001279569-16-002872 Sample Contracts

Amended and Restated At Market Issuance Sales Agreement
At Market Issuance Sales Agreement • March 7th, 2016 • Cardiome Pharma Corp • Pharmaceutical preparations • New York

Cardiome Pharma Corp. (the “Company”), a corporation formed under the Canada Business Corporations Act (the “CBCA”), confirms its agreement (this “Agreement”) with FBR Capital Markets & Co. (“FBR”) and MLV & Co. LLC (“MLV”, each of FBR and MLV, individually a “Distribution Agent”, and collectively, the “Distribution Agents”), to amend and restate the At Market Issuance Sales Agreement dated February 18, 2014 between the Company and MLV, as follows:

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