0001299933-05-004073 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New Jersey

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”), dated as of August 4, 2005, by and among THE IMMUNE RESPONSE CORPORATION, a Delaware corporation (the “Company”), and the Buyers listed on Schedule I attached hereto (individually, a “Buyer” or collectively “Buyers”).

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INVESTOR REGISTRATION RIGHTS AGREEMENT
Investor Registration Rights Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New Jersey

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of August 4, 2005, by and among THE IMMUNE RESPONSE CORPORATION, a Delaware corporation (the “Company”), and the undersigned investors listed on Schedule I attached hereto (each, an “Investor” and collectively, the “Investors”).

SECURITY AGREEMENT
Security Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New Jersey

THIS SECURITY AGREEMENT (the “Agreement”), is entered into and made effective as of August 4, 2005, by and between THE IMMUNE RESPONSE CORPORATION, a Delaware corporation with its principal place of business located at 5391 Darwin Court, Carlsbad, CA 92008 (the “Company”), and the BUYER(S) listed on Schedule I attached to the Securities Purchase Agreement dated the date hereof (the “Secured Party”).

PLEDGE AND ESCROW AGREEMENT
Pledge and Escrow Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New Jersey

THIS PLEDGE AND ESCROW AGREEMENT (the “Agreement”) is made and entered into as of August 4, 2005 (the “Effective Date”) by and among THE IMMUNE RESPONSE CORPORATION, a corporation organized and existing under the laws of the State of Delaware (the “Pledgor”), CORNELL CAPITAL PARTNERS, LP (the “Pledgee”), and DAVID GONZALEZ, ESQ., as escrow agent (“Escrow Agent”).

Contract
182 Warrant Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New York

WARRANT AGREEMENT (this “Agreement”), dated as of August 4, 2005 by and between The Immune Response Corporation, a Delaware corporation (the “Company”), and Cheshire Associates LLC, a Delaware limited liability company (the “Warrant Holder”).

INSIDER PLEDGE AND ESCROW AGREEMENT
Insider Pledge and Escrow Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New Jersey

THIS INSIDER PLEDGE AND ESCROW AGREEMENT (the “Agreement”) is made and entered into as of August 4, 2005 (the “Effective Date”) by and among CHESHIRE ASSOCIATES LLC (the “Pledgor”), CORNELL CAPITAL PARTNERS, LP (the “Pledgee”), THE IMMUNE RESPONSE CORPORATION, a Delaware corporation (the “Company”), and DAVID GONZALEZ, ESQ., as escrow agent (“Escrow Agent”).

Contract
181 Pledge Inducement Agreement • August 9th, 2005 • Immune Response Corp • Biological products, (no disgnostic substances) • New York

This PLEDGE INDUCEMENT AGREEMENT (this “Agreement”), dated as of August 4, 2005, is by and between The Immune Response Corporation, a Delaware corporation (the “Company”), and Cheshire Associates LLC, a Delaware limited liability company (“Cheshire”).

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