0001354488-15-001926 Sample Contracts

PERNIX THERAPEUTICS HOLDINGS, INC. AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of April 22, 2015

Indenture • April 24th, 2015 • Pernix Therapeutics Holdings, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Indenture
• Filed
  April 24th, 2015
• Company
  Pernix Therapeutics Holdings, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

PERNIX THERAPEUTICS HOLDINGS, INC. AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee THIRD SUPPLEMENTAL INDENTURE Dated as of April 21, 2015

Third Supplemental Indenture • April 24th, 2015 • Pernix Therapeutics Holdings, Inc. • Pharmaceutical preparations

• Contract Type
  Third Supplemental Indenture
• Filed
  April 24th, 2015
• Company
  Pernix Therapeutics Holdings, Inc.
• Industry
  Pharmaceutical preparations

THIS THIRD SUPPLEMENTAL INDENTURE (this “Third Supplemental Indenture”), entered into as of April 21, 2015, among Pernix Therapeutics Holdings, Inc., a Maryland corporation (the “Company”) party hereto and Wilmington Trust, National Association, a national banking association (the “Trustee”).

PERNIX THERAPEUTICS HOLDINGS, INC. AND as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of April 21, 2015 12% Senior Secured Notes due 2020

First Supplemental Indenture • April 24th, 2015 • Pernix Therapeutics Holdings, Inc. • Pharmaceutical preparations

• Contract Type
  First Supplemental Indenture
• Filed
  April 24th, 2015
• Company
  Pernix Therapeutics Holdings, Inc.
• Industry
  Pharmaceutical preparations

THIS FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), entered into as of April 21, 2015, among Pernix Therapeutics Holdings, Inc., a Maryland corporation (the “Company”) and U.S. Bank National Association, as trustee (the “Trustee”).