BAXALTA INCORPORATED, as Issuer, SHIRE LIMITED, as Guarantor TAKEDA PHARMACEUTICAL COMPANY LIMITED as Guarantor, and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee FOURTH SUPPLEMENTAL INDENTURE DATED as of July 2, 2019 TO THE INDENTURE...Fourth Supplemental Indenture • August 9th, 2019 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations • New York
