0001395064-20-000110 Sample Contracts

AMENDMENT NO. 2 Dated as of December 25, 2019 to JBIC LOAN TO TAKEDA
Loan Agreement • June 24th, 2020 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations

THIS AMENDMENT NO. 2 (this “Amendment”) is made as of December 25, 2019 by and among Takeda Pharmaceutical Company Limited, a joint-stock company organized and existing under the laws of Japan, (the “Company”) and Japan Bank for International Cooperation (“JBIC”), under that certain Loan Agreement dated as of December 3, 2018 and as amended by Amendment No.1 dated December 25, 2018 (as amended, restated, supplemented or otherwise modified from time to time prior to the date hereof, the “Loan Agreement”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings given to them in the Loan Agreement.

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AMENDMENT NO. 2 Dated as of October 18, 2019 to TERM LOAN CREDIT AGREEMENT
Term Loan Credit Agreement • June 24th, 2020 • Takeda Pharmaceutical Co LTD • Pharmaceutical preparations • New York

THIS AMENDMENT NO. 2 (this “Amendment”) is made as of October 18, 2019 by and among Takeda Pharmaceutical Company Limited, a joint-stock company organized and existing under the laws of Japan, (the “Company”), the financial institutions listed on the signature pages hereof and JPMorgan Chase Bank, N.A., as Administrative Agent (the “Administrative Agent”), under that certain Term Loan Credit Agreement dated as of June 8, 2018 by and among the Company, the Lenders and the Administrative Agent, and amended by Amendment No. 1 dated December 20, 2018 (as amended, restated, supplemented or otherwise modified from time to time prior to the date hereof, the “Credit Agreement”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings given to them in the Credit Agreement.

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