0001403752-21-000005 Sample Contracts

AMENDMENT NO. 2 TO LICENSE AGREEMENT
License Agreement • February 24th, 2021 • Zymeworks Inc. • Pharmaceutical preparations

THIS AMENDMENT NO. 2 TO LICENSE AGREEMENT (the “Amendment”) is entered by and between Zymeworks Inc., a corporation organized and existing under the laws of British Columbia, having a place of business at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9 (“Zymeworks”), and Iconic Therapeutics, Inc., a Delaware corporation, having an address 442 Littlefield Avenue, South San Francisco, California 94080 USA (“ICONIC”), with effect as of the last date set forth under the signatures of the Parties below (the “Amendment Effective Date” ). Zymeworks and ICONIC may be referred to herein individually as a “Party” and collectively as the “Parties.”

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FIFTH AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • February 24th, 2021 • Zymeworks Inc. • Pharmaceutical preparations • Delaware

This Fifth Amendment (the “Amendment”) to that certain Collaboration and License Agreement, dated December 1, 2015, as amended on April 30, 2019 and by letter agreement on January 11, 2019, September 30, 2019 and February 20, 2020 (collectively, the “Agreement”) by and between GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED, a corporation organized and existing under the laws of England and Wales, with its registered office located at 980 Great West Road, Brentford, Middlesex, TW8 9GS, United Kingdom (“GSK”) and ZYMEWORKS INC., a corporation organized and existing under the laws of British Columbia, having an address at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9 (“Zymeworks”), is entered into as of March 30, 2020 (the “Fifth Amendment Effective Date”). Zymeworks and GSK are each referred to individually as a “Party” and together as the “Parties.”

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