0001437749-23-013739 Sample Contracts

EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • May 11th, 2023 • Diffusion Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts

This Executive Employment Agreement (the “Agreement”), made and entered into this 2nd day of April, 2018 (the “Effective Date”), by and between EIP Pharma, Inc. (“Company”), and Sylvie Gregoire (“Executive”).

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OPTION AND LICENSE AGREEMENT BY AND BETWEEN EIP PHARMA LLC AND VERTEX PHARMACEUTICALS INCORPORATED
Option and License Agreement • May 11th, 2023 • Diffusion Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts

This Option and License Agreement (this “Agreement”), made this 27th day of August, 2012 (the “Effective Date”), is by and between DP Pharma LLC, a Massachusetts limited liability company, with principal offices located at 11 Channing Street, Cambridge, MA 02138 (“EIP”) and Vertex Pharmaceuticals Incorporated, a Delaware corporation, with principal offices located at 130 Waverly Street, Cambridge, MA 02139 (“Vertex”). Each of EIP and Vertex may be referred to, individually, as a “Party”, and, collectively, as the “Parties”.

AMENDMENT NO. 1 OPTION AND LICENSE AGREEMENT
Option and License Agreement • May 11th, 2023 • Diffusion Pharmaceuticals Inc. • Pharmaceutical preparations

This Amendment No. 1 (this “Amendment”) to that certain Option and License Agreement by and between EIP Pharma LLC, a Massachusetts limited liability company, with principal offices located at 11 Channing Street, Cambridge, MA 02138 (“EIP”) and Vertex Pharmaceuticals Incorporated, a Massachusetts corporation, with principal offices located at 130 Waverly Street, Cambridge, MA 02139 (“Vertex”) effective as of August 27, 2012 (the “Option and License Agreement”) is effective as of as of April 8, 2014 (“Amendment Effective Date”). Capitalized terms used herein but not defined herein will have the meaning set forth in the Option and Lease Agreement. The Parties agree to amend the Option and License Agreement as follows:

AMENDMENT NO. 2 OPTION AND LICENSE AGREEMENT
Option and License Agreement • May 11th, 2023 • Diffusion Pharmaceuticals Inc. • Pharmaceutical preparations

This Amendment No. 2 (this “Amendment”) to that certain Option and License Agreement by and between EIP Pharma LLC, a Massachusetts limited liability company, with principal offices located at 11 Channing Street, Cambridge, MA 02138 (“EIP”) and Vertex Pharmaceuticals Incorporated, a Massachusetts corporation, with principal offices located at 50 Northern Avenue, Boston, MA 02210 (“Vertex”) effective as of August 27, 2012, as amended April 18, 2014 (the “Option and License Agreement”) is effective as of November 17, 2015 (“Amendment Effective Date”). Capitalized terms used herein but not defined herein will have the meaning set forth in the Option and License Agreement. The Parties agree to amend the Option and License Agreement as follows:

AMENDMENT NO. 1 TO EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • May 11th, 2023 • Diffusion Pharmaceuticals Inc. • Pharmaceutical preparations

This Amendment No. 1 to Executive Employment (the “Amendment”) is made and entered into as of March 4, 2019, by and between EIP Pharma, Inc. (the “Company”) and Sylvie Grégoire (the “Executive”). Capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to such terms in that certain Executive Employment Agreement, dated as of April 2, 2018, by and between Company and Executive (the “Agreement”).

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