0001437749-23-019025 Sample Contracts

SECOND AMENDMENT TO SUPPLEMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • June 30th, 2023 • Clene Inc. • Pharmaceutical preparations

This Second Amendment to Supplement to Loan and Security Agreement (this “Amendment”) is entered into as of June 27, 2023, by and among AVENUE VENTURE OPPORTUNITIES FUND, L.P., a Delaware limited partnership (“Lender”) and CLENE INC., a Delaware corporation and CLENE NANOMEDICINE, INC., a Delaware corporation (individually and collectively, jointly and severally, “Borrower”).

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