0001437749-24-014395 Sample Contracts

SEVENTH AMENDMENT TO NOTE PURCHASE AGREEMENT AND THIRD AMENDMENT TO DISCLOSURE LETTER
Note Purchase Agreement • May 2nd, 2024 • Puma Biotechnology, Inc. • Pharmaceutical preparations

This SEVENTH AMENDMENT TO NOTE PURCHASE AGREEMENT AND THIRD AMENDMENT TO DISCLOSURE LETTER (this “Agreement”), dated as of April 12, 2024, is entered into by and among PUMA BIOTECHNOLOGY, INC., a Delaware corporation (the “Issuer”), the Guarantors party hereto, the Purchasers party hereto and ATHYRIUM OPPORTUNITIES IV CO-INVEST 1 LP, as the Administrative Agent. All capitalized terms used herein and not otherwise defined herein shall have the meanings given to such terms in the Note Purchase Agreement (as defined below).

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