0001445305-11-000984 Sample Contracts

SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • May 24th, 2011 • Medicines Co /De • Pharmaceutical preparations • New York

This Second Amended and Restated Distribution Agreement (together with its schedules and exhibits, the “Agreement”) is entered into by The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (the “Distributor”), effective as of October 1, 2010 (the “Effective Date”).

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