0001494650-24-000027 Sample Contracts

SECOND AMENDMENT TO NOTE PURCHASE AGREEMENT
Note Purchase Agreement • March 8th, 2024 • OptiNose, Inc. • Pharmaceutical preparations

This Second Amendment to the Note Purchase Agreement (defined below) (this “Amendment”), dated as of March 8. 2024 (the “Second Amendment Effective Date”), is entered into by and among OPTINOSE US, INC., a Delaware corporation (the “Issuer”), OPTINOSE, INC., a Delaware corporation (the “Parent”), the Purchasers (as defined in the Note Purchase Agreement) party to the Note Purchase Agreement as of the Second Amendment Effective Date, and BIOPHARMA CREDIT PLC, a public limited company incorporated under the laws of England and Wales, as Collateral Agent.

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