0001516551-22-000004 Sample Contracts

RESTATED AND AMENDED LICENSE AGREEMENT

And Amended License Agreement • March 28th, 2022 • Skye Bioscience, Inc. • Pharmaceutical preparations • Mississippi

• Contract Type
  And Amended License Agreement
• Filed
  March 28th, 2022
• Company
  Skye Bioscience, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Mississippi

THIS RESTATED AND AMENDED LICENSE AGREEMENT ("Agreement") is made as of this May 24, 2019 ("Effective Date") by and between the UNIVERSITY OF MISSISSIPPI, SCHOOL OF PHARMACY, an educational institution with a principal address at University, Mississippi 38677 ("UM"), and EMERALD BIOSCIENCE, INC. f/k/a Nemus Bioscience, Inc., a corporation organized and existing under the laws of Nevada with a principal address at 130 North Marina Drive, Long Beach, CA 90803 ("Licensee").

Skye Bioscience, Inc. Skye Bioscience, Inc. 2014 Omnibus Incentive Plan, as amended Restricted Stock Unit Agreement

Restricted Stock Unit Agreement • March 28th, 2022 • Skye Bioscience, Inc. • Pharmaceutical preparations • California

• Contract Type
  Restricted Stock Unit Agreement
• Filed
  March 28th, 2022
• Company
  Skye Bioscience, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  California

Skye Bioscience, Inc., a Nevada corporation, (the “Company”), hereby grants Restricted Stock Units (to the individual named below as the Participant, subject to the vesting requirements and other terms and conditions set forth in this Restricted Stock Unit Agreement, including the attached Terms and Conditions and any appendix attached hereto (together, the “Agreement”). This grant is subject to the terms and conditions set forth in this Agreement and the Skye Bioscience, Inc. 2014 Omnibus Incentive Plan, as amended (the “Plan”). Capitalized terms not defined in this Agreement are defined in the Plan, and have the meaning set forth in the Plan.

AMENDMENT NO. 3 MULTI DRAW CREDIT AGREEMENT

Multi Draw Credit Agreement • March 28th, 2022 • Skye Bioscience, Inc. • Pharmaceutical preparations • California

• Contract Type
  Multi Draw Credit Agreement
• Filed
  March 28th, 2022
• Company
  Skye Bioscience, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  California

This Amendment (this “Amendment”) is made and entered into as of September 15, 2021, by and between Skye Bioscience, Inc., a corporation incorporated under the laws of the state of Nevada (the “Company”), and Emerald Health Sciences Inc., a corporation incorporated under the laws of British Columbia (the “Lender”). The above parties are referred to collectively herein as the “Parties,” and individually as a “Party.”