0001532063-15-000004 Sample Contracts

FOURTEENTH SUPPLEMENTAL INDENTURE
Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Fourteenth Supplemental Indenture (this “Fourteenth Supplemental Indenture”), dated as of February 2, 2015, among Express Scripts Holding Company (formerly Aristotle Holding, Inc.), a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and Wells Fargo Bank, National Association, as trustee under the indenture referred to below (the “Trustee”).

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FOURTH SUPPLEMENTAL INDENTURE
Fourth Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Fourth Supplemental Indenture (this “Fourth Supplemental Indenture”), dated as of February 2, 2015, among Medco Health Solutions, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and U.S. Bank Trust National Association, as trustee under the indenture referred to below (the “Trustee”).

ELEVENTH SUPPLEMENTAL INDENTURE
Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Eleventh Supplemental Indenture (this “Eleventh Supplemental Indenture”), dated as of February 2, 2015, among Express Scripts, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and MUFG Union Bank, N.A., a national banking association, as trustee under the indenture referred to below (the “Trustee”).

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