0001532063-15-000004 Sample Contracts

FOURTEENTH SUPPLEMENTAL INDENTURE

Fourteenth Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

• Contract Type
  Fourteenth Supplemental Indenture
• Filed
  February 23rd, 2015
• Company
  Express Scripts Holding Co.
• Industry
  Retail-drug stores and proprietary stores
• Jurisdiction
  New York

The Fourteenth Supplemental Indenture (this “Fourteenth Supplemental Indenture”), dated as of February 2, 2015, among Express Scripts Holding Company (formerly Aristotle Holding, Inc.), a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and Wells Fargo Bank, National Association, as trustee under the indenture referred to below (the “Trustee”).

FOURTH SUPPLEMENTAL INDENTURE

Fourth Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

• Contract Type
  Fourth Supplemental Indenture
• Filed
  February 23rd, 2015
• Company
  Express Scripts Holding Co.
• Industry
  Retail-drug stores and proprietary stores
• Jurisdiction
  New York

The Fourth Supplemental Indenture (this “Fourth Supplemental Indenture”), dated as of February 2, 2015, among Medco Health Solutions, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and U.S. Bank Trust National Association, as trustee under the indenture referred to below (the “Trustee”).

ELEVENTH SUPPLEMENTAL INDENTURE

Eleventh Supplemental Indenture • February 23rd, 2015 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

• Contract Type
  Eleventh Supplemental Indenture
• Filed
  February 23rd, 2015
• Company
  Express Scripts Holding Co.
• Industry
  Retail-drug stores and proprietary stores
• Jurisdiction
  New York

The Eleventh Supplemental Indenture (this “Eleventh Supplemental Indenture”), dated as of February 2, 2015, among Express Scripts, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), Strategic Pharmaceutical Investments, LLC (the “Additional Guarantor”), and MUFG Union Bank, N.A., a national banking association, as trustee under the indenture referred to below (the “Trustee”).