0001532063-16-000017 Sample Contracts

FIFTEENTH SUPPLEMENTAL INDENTURE
Fifteenth Supplemental Indenture • February 16th, 2016 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Fifteenth Supplemental Indenture (this “Fifteenth Supplemental Indenture”), dated as of October 29, 2015, among Express Scripts Holding Company (formerly Aristotle Holding, Inc.), a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), L&C Investment, LLC (the “Additional Guarantor”), and Wells Fargo Bank, National Association, as trustee under the indenture referred to below (the “Trustee”).

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AMENDMENT
Express Scripts Holding Co. • February 16th, 2016 • Retail-drug stores and proprietary stores

The parties have previously entered into a Capped Accelerated Share Repurchase Transaction dated as of April 29, 2015, (the “Confirmations”). The parties have agreed to amend the Confirmations in accordance with the terms of this Amendment (the “Amendment”).

FIFTH SUPPLEMENTAL INDENTURE
Fifth Supplemental Indenture • February 16th, 2016 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Fifth Supplemental Indenture (this “Fifth Supplemental Indenture”), dated as of October 29, 2015, among Medco Health Solutions, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), L&C Investment, LLC (the “Additional Guarantor”), and U.S. Bank Trust National Association, as trustee under the indenture referred to below (the “Trustee”).

TWELFTH SUPPLEMENTAL INDENTURE
Twelfth Supplemental Indenture • February 16th, 2016 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York

The Twelfth Supplemental Indenture (this “Twelfth Supplemental Indenture”), dated as of October 29, 2015, among Express Scripts, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), L&C Investment, LLC (the “Additional Guarantor”), and MUFG Union Bank, N.A., a national banking association, as trustee under the indenture referred to below (the “Trustee”).

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