0001558370-16-003498 Sample Contracts

LICENSE AGREEMENT
License Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations

This Agreement is made as of the 21 day February of 1996, between MEDISORB TECHNOLOGIES INTERNATIONAL L.P., a Delaware limited partnership (hereinafter "Medisorb") and JANSSEN PHARMACEUTICA INTERNATIONAL, a division of Cilag International AG, a Swiss business corporation ("Janssen").

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SEPARATION AGREEMENT
Separation Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations • Massachusetts

This Separation Agreement (the “Separation Agreement”) is made between Rebecca J. Peterson (“Executive”) and Alkermes, Inc. (the “Company,” together with Executive, the “Parties”).

Alkermes Controlled Therapeutics Inc. II Cambridge, MA 02139 USA
And Supply Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations

Pursuant to that certain Manufacturing and Supply Agreement (the “Agreement”), dated August 6, 1997, among Alkermes Controlled Therapeutics Inc. II (“ACT II”), JPI Pharmaceutica International, a division of Cilag AG International Zug, a company organized under the laws of Switzerland (“JPI”), and Janssen Pharmaceutica Inc. (“Janssen US”) (JPI and Janssen US collectively referred to herein as “Janssen”), as supplemented by that certain Addendum to Manufacturing and Supply Agreement (the “Addendum”), dated August 1, 2001, among ACT II, JPI and Janssen, certain exhibits referred to in the Agreement would be agreed to by the parties in the future. Those exhibits are Exhibits A, B, E, F, G and H. This letter sets forth the agreement by the parties as to such Exhibits.

MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations

JPI PHARMACEUTICA INTERNATIONAL, a division of Cilag AG International Zug, a company duly organized and existing under the laws of Switzerland, having its principal office in CH-6300 Zug, Kollerstrasse 38, Switzerland (hereinafter referred to as "JPI")

LICENSE AGREEMENT
License Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations

This Agreement is made as of the 13 day February of 1996, between MEDISORB TECHNOLOGIES INTERNATIONAL L.P., a Delaware limited partnership (hereinafter "Medisorb") and JANSSEN PHARMACEUTICA INC., a New Jersey corporation ("Janssen US").

ADDENDUM TO MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • February 25th, 2016 • Alkermes Plc. • Pharmaceutical preparations

This Addendum to Manufacturing and Supply Agreement (this “Addendum”), dated as of the 1 day of August, 2001 (the “Effective Date”) is by and between JPI PHARMACEUTICA INTERNATIONAL, a division of Cilag AG International Zug, a company duly organized and existing under the laws of Switzerland, having its principal office in CH- 6300 Zug, Kollerstrasse 38, Switzerland (“JPI”) and JANSSEN PHARMACEUTICA Inc., 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA (“Janssen US” and, together with JPI, “Janssen”) on the one hand and Alkermes Controlled Therapeutics Inc. II, a company organized and existing under the laws of the Commonwealth of Pennsylvania, having its principal office at 64 Sidney Street, Cambridge MA 02139-4136, USA (“ACTII”) on the other hand.

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