0001558370-16-009951 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • November 10th, 2016 • Blueprint Medicines Corp • Pharmaceutical preparations • Massachusetts

This Employment Agreement (“Agreement”) is dated as of September 6, 2016 (the “Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Tracey McCain (the “Executive”).

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MASTER COLLABORATION AGREEMENT
Master Collaboration Agreement • November 10th, 2016 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

Blueprint is a global pharmaceutical company engaged in the research, development, manufacture and commercialization of pharmaceutical products to treat disease;

THIRD AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 10th, 2016 • Blueprint Medicines Corp • Pharmaceutical preparations

This Third Amendment (this “Amendment”), effective August 4, 2016 (“Effective Date”), is by and between F. Hoffmann-La Roche Ltd, with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland and Hoffmann-La Roche Inc., with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. (together referred to as “Roche”) and Blueprint Medicines Corporation, located at 38 Sidney Street, Suite 200, Cambridge, Massachusetts 02139 (“Blueprint”).

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