0001558370-18-000941 Sample Contracts

EXACT SCIENCES CORPORATION 2010 OMNIBUS LONG-TERM INCENTIVE PLAN (As Amended and Restated Effective JULY 27, 2017) Restricted Stock Unit Award Agreement
Restricted Stock Unit Award Agreement • February 22nd, 2018 • Exact Sciences Corp • Services-commercial physical & biological research • Delaware

This Restricted Stock Unit Award Agreement (“Award Agreement”) is made between Exact Sciences Corporation, a Delaware corporation (the “Company”), and you, a Service Provider to the Company (“Grantee”).

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Incentive Stock Option Award Agreement
Incentive Stock Option Award Agreement • February 22nd, 2018 • Exact Sciences Corp • Services-commercial physical & biological research • Delaware

Exact Sciences Corporation, a Delaware corporation, hereby grants to you (the Grantee named below), and you hereby accept, an Option on the following terms and subject to the terms and conditions specified in the attached Terms and Conditions.

SECOND AMENDMENT TO MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH AMENDED AND RESTATED LICENSE AGREEMENT
License Agreement • February 22nd, 2018 • Exact Sciences Corp • Services-commercial physical & biological research

This Second Amendment (this “Amendment”) to the Mayo Foundation for Medical Education and Research Amended and Restated License Agreement dated effective January 31, 2015 (“Restated Agreement”), is entered into between MAYO Foundation for Medical Education and Research, (“MAYO”), Exact Sciences Corporation (“EXACT”), and Exact Sciences Development Company, LLC (“ESDC”), a wholly-owned subsidiary of EXACT. This Amendment is executed on the dates indicated below, but shall be deemed effective as of October 1, 2017 (“Amendment Effective Date”).

EXACT SCIENCES CORPORATION (AS AMENDED AND RESTATED EFFECTIVE JULY 27, 2017) Restricted Stock Award Agreement
Restricted Stock Award Agreement • February 22nd, 2018 • Exact Sciences Corp • Services-commercial physical & biological research

This Restricted Stock Award Agreement (“Award Agreement”) is made between Exact Sciences Corporation, a Delaware corporation, (the “Company”) and you (“Grantee”).

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