0001558370-18-001248 Sample Contracts

LOAN AGREEMENT
Loan Agreement • February 28th, 2018 • TESARO, Inc. • Pharmaceutical preparations • New York

THIS LOAN AGREEMENT (this “Agreement”), dated as of November 21, 2017 (the “Effective Date”) by and among TESARO, INC., a Delaware corporation (as “Borrower”), TESARO SECURITIES CORPORATION, a Massachusetts corporation (as an additional Credit Party), BIOPHARMA CREDIT PLC, a public limited company incorporated under the laws of England and Wales (as “Collateral Agent” and a “Lender”) and BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (as a “Lender”), provides the terms on which each Lender shall make, and Borrower shall repay, the Credit Extensions (as hereinafter defined). The parties hereto agree as follows:

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SEVENTH AMENDMENT TO LEASE
Lease • February 28th, 2018 • TESARO, Inc. • Pharmaceutical preparations

SEVENTH AMENDMENT TO LEASE (this “Seventh Amendment”) dated as of this 10th day of October, 2017 (the “Seventh Amendment Effective Date”) by and between BP BAY COLONY LLC, a Delaware limited liability company (“Landlord”), and TESARO, INC., a Delaware corporation (“Tenant”).

BAY COLONY CORPORATE CENTER WALTHAM, MASSACHUSETTS Lease Dated December 18, 2017
Work Agreement • February 28th, 2018 • TESARO, Inc. • Pharmaceutical preparations • Massachusetts

THIS INSTRUMENT IS AN INDENTURE OF LEASE in which the Landlord and the Tenant are the parties hereinafter named, and which relates to space in a certain building (the “Building”) known as, and with an address at, 1100 Winter Street, Waltham, Massachusetts 02451.

Collaboration, Development and License Agreement
Development and License Agreement • February 28th, 2018 • TESARO, Inc. • Pharmaceutical preparations • New York

THIS AMENDMENT TO COLLABORATION, DEVELOPMENT AND LICENSE AGREEMENT (the “Amendment”) is made and entered into as of February 26, 2018 by and among TESARO, Inc., a Delaware corporation (“TESARO Inc.”), TESARO Development Ltd., a Bermuda corporation (“TSRO Ltd.” and together with TESARO Inc., “TESARO”), and Zai Lab (Shanghai) Co., Ltd., a limited liability company organized under the laws of the People’s Republic of China (“Zai” and together with TESARO, the “Parties”).

FIRST AMENDMENT TO LOAN AGREEMENT
Loan Agreement • February 28th, 2018 • TESARO, Inc. • Pharmaceutical preparations • New York

This First Amendment to the Loan Agreement (defined below) (this “Amendment”), dated as of February 7, 2018 (the “Effective Date”), is entered into by and among TESARO, INC., a Delaware corporation (as “Borrower”), TESARO SECURITIES CORPORATION, a Massachusetts corporation (as an additional Credit Party), BIOPHARMA CREDIT PLC, a public limited company incorporated under the laws of England and Wales (as “Collateral Agent” and a “Lender”) and BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (as a “Lender”).

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