0001558370-20-002278 Sample Contracts

DATED 26 September 2019 BicycleTX Ltd and Nigel Crockett SERVICE AGREEMENT
Service Agreement • March 10th, 2020 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • England and Wales
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AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • March 10th, 2020 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • Massachusetts

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of September 26th, 2019 (the “Effective Date”), by and between Nicholas Keen (“Executive”) and Bicycle Therapeutics Inc. (the “Company”).

DISCOVERY COLLABORATION AND LICENSE AGREEMENT between BICYCLETX LIMITED and GENENTECH, INC. Dated as of February 21, 2020
Discovery Collaboration and License Agreement • March 10th, 2020 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • New York

This Discovery Collaboration and License Agreement (the “Agreement”) is made and entered into effective as of February 21, 2020 (the “Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales (“BicycleTx”), and Genentech, Inc., a Delaware corporation (“Genentech”). BicycleTx and Genentech are referred to herein individually as a “Party” and collectively as the “Parties”.

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