0001558370-21-000147 Sample Contracts

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • January 11th, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Employment Agreement (the “First Amendment”) between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Anthony L. Boral (the “Executive”), is effective as of January 11, 2021 (the “Amendment Effective Date”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

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AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • January 11th, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations • Massachusetts

This amended and restated employment agreement (“Agreement”) is between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and L. Becker Hewes, M.D. (the “Executive”) and is effective as of January 11, 2021 (the “Effective Date”).

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