0001558370-21-009477 Sample Contracts

SECOND AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • July 28th, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment, effective April 27, 2016 (“Effective Date”), is by and between F. Hoffmann-La Roche Ltd, with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland and Hoffmann-La Roche Inc., with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. (together referred to as “Roche”) and Blueprint Medicines, located at 38 Sidney Street, Cambridge, Massachusetts 02139 (“Blueprint”).

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Collaboration and License Agreement
Supply Agreement 9.1 • July 28th, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations • New York

with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. ("Roche US"; Roche Basel and Roche US together referred to as "Roche")

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