0001558370-22-002457 Sample Contracts

BICYCLETX LIMITED​and​ALISTAIR MILNES SERVICE AGREEMENT
Service Agreement • March 1st, 2022 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • England and Wales
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AMENDMENT NO. 1 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • March 1st, 2022 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 to Collaboration and License Agreement (“First Amendment”) is made and entered into effective as of December 17, 2021 (“First Amendment Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales with a place of business at Building 900, Babraham Research Campus, Cambridge CB22 3AT, UK (“BicycleTx”), and Ionis Pharmaceuticals, Inc., a Delaware corporation with a principal place of business at 2855 Gazelle Court, Carlsbad, California 92010, USA (“Ionis”). BicycleTx and Ionis are referred to herein individually as a “Party” and collectively as the “Parties”.

Amendment to your service agreement with BicycleTX Limited (the “Company”) dated 26 September 2019 (the “Service Agreement”)
Service Agreement • March 1st, 2022 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

Following our recent discussions regarding a move from the Chief Operating Officer role to the new Chief Technology Officer role, I am happy to write to you to confirm this agreed move and to confirm the applicable amendments to the terms set out in your Service Agreement.

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