0001558370-22-002788 Sample Contracts

Amendment to Incentive Stock Option Agreement (Employees) Issued under Amended and Restated Stock Incentive Plan
Incentive Stock Option Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

This Amendment to Nonqualified Stock Option Agreement (Employees) (“Amendment”) issued under the Amended and Restated Stock Incentive Plan (the “Plan”) of Entasis Therapeutics Holdings Inc. (the “Company”) is made effective as of November 10, 2021 (“Effective Date”) and modifies the outstanding Incentive Stock Options Agreement(s) (Senior Management) (“Option Agreements”) existing as of the Effective Date between the Company and Optionee. Capitalized terms not explicitly defined in this Amendment or the Option Agreement(s), shall have the meanings set forth in the Plan.

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Amendment to Nonqualified Stock Option Agreement (Senior Management) Issued under Amended and Restated Stock Incentive Plan
Nonqualified Stock Option Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

This Amendment to Nonqualified Stock Option Agreement (Senior Management) (“Amendment”) issued under the Amended and Restated Stock Incentive Plan (the “Plan”) of Entasis Therapeutics Holdings Inc. (the “Company”) is made effective as of November 10, 2021 (“Effective Date”) and modifies the outstanding Non-Qualified Stock Options Agreement(s) (Senior Management) (“Option Agreements”) existing as of the Effective Date between the Company and Optionee. Capitalized terms not explicitly defined in this Amendment or the Option Agreement(s), shall have the meanings set forth in the Plan.

ENTASIS THERAPEUTICS HOLDINGS INC. RESTRICTED STOCK UNIT GRANT AGREEMENT (EMPLOYEE/D & O)
Restricted Stock Unit Award Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

Pursuant to the Restricted Stock Unit Grant notice (the “Grant Notice”) and this Restricted Stock Unit Award Agreement (the “Agreement”), Entasis Therapeutics Holdings Inc. (the “Company”) has awarded you (“Participant”) a Restricted Stock Unit Award (the “Award”) pursuant to the Company’s 2018 Equity Incentive Plan (the “Plan”) to be issued the number of Restricted Stock Units/shares indicated in the Grant Notice. Capitalized terms not explicitly defined in this Agreement or the Grant Notice shall have the same meanings given to them in the Plan. The terms of your Award, in addition to those set forth in the Grant Notice and the Plan, are as follows:

Amendment to Option Agreement Issued under 2018 Equity Incentive Plan
Option Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

This Amendment to Option Agreement (“Amendment”) issued under the 2018 Equity Incentive Plan (the “Plan”) of Entasis Therapeutics Holdings Inc.’s (the “Company”) is made effective as of November 10, 2021 (“Effective Date”) and modifies the Option Agreement(s) existing as of the Effective Date between the Company and Optionholder. Capitalized terms not explicitly defined in this Amendment or the Option Agreement, shall the meaning set forth in the Plan.

OPTION AGREEMENT (AMENDED) (EMPLOYEES/D & Os) (2018 EQUITY INCENTIVE PLAN) (INCENTIVE STOCK OPTION OR NONSTATUTORY STOCK OPTION)
Option Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

Pursuant to your Stock Option Grant Notice (“Grant Notice”) and this Option Agreement (Amended), Entasis Therapeutics Holdings Inc. (the “Company”) has granted you an option under its 2018 Equity Incentive Plan (the “Plan”) to purchase the number of shares of the Company’s Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. The option is granted to you effective as of the date of grant set forth in the Grant Notice (the “Date of Grant”). If there is any conflict between the terms in this Option Agreement and the Plan, the terms of the Plan will control. Capitalized terms not explicitly defined in this Option Agreement or in the Grant Notice but defined in the Plan will have the same definitions as in the Plan.

Amendment to Restricted Stock Unit Grant Agreement Issued under 2018 Equity Incentive Plan
Restricted Stock Unit Grant Agreement • March 3rd, 2022 • Entasis Therapeutics Holdings Inc. • Pharmaceutical preparations

This Amendment to Restricted Stock Unit Grant Agreement (“Amendment”) issued under the 2018 Equity Incentive Plan (the “Plan”) of Entasis Therapeutics Holdings Inc. (the “Company”) is made effective as of November 10, 2021 (“Effective Date”) and modifies the outstanding Restricted Stock Unit Agreement(s) (“RSU Agreements”) existing as of the Effective Date between the Company and Participant. Capitalized terms not explicitly defined in this Amendment or the Option Agreement, shall have the meanings set forth in the Plan.

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