0001558370-23-007979 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • Massachusetts

This Employment Agreement (the “Agreement”) is entered into effective as of 31st March 2023 (the “Effective Date”), by and between Santiago Arroyo (“Executive”) and Bicycle Therapeutics Inc. (the “Company”).

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Amendment No. 1 to Service Agreement
Service Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 (“Amendment No. 1”) to Service Agreement dated 5 January 2022 (the “Employment Agreement”) is entered into by the following Parties: BicycleTX Limited (the “Company”) and Alistair Milnes (“you”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

Contract
Licence Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • New York

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

Amendment No. 2 to Service Agreement
Service Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 2 (“Amendment No. 2”) to Service Agreement dated 26 September 2019, as amended on 5 January 2022 (the “Employment Agreement”) is entered into by the following Parties: BicycleTX Limited (the “Company”) and Dr. Michael Skynner (“you”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

Amendment No. 1 to Service Agreement
Service Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 (“Amendment No. 1”) to Service Agreement dated 9 July 2020 (the “Employment Agreement”) is entered into by the following Parties: BicycleTX Limited (the “Company”) and Dominic Smethurst (“you”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

Amendment No. 1 to Amended and Restated Employment Agreement
Employment Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 (“Amendment No. 1”) to Amended and Restated Employment Agreement, effective as of September 26, 2019 (the “Employment Agreement”) is entered into by the following Parties: Bicycle Therapeutics Inc. (the “Company”) and Nicholas Keen (“Executive”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

Amendment No. 1 to Amended and Restated Employment Agreement
Employment Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 (“Amendment No. 1”) to Amended and Restated Employment Agreement, effective as of September 26, 2019 (the “Employment Agreement”) is entered into by the following Parties: Bicycle Therapeutics Inc. (the “Company”) and Lee Kalowski (“Executive”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

Amendment No. 1 to Service Agreement
Service Agreement • May 4th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 1 (“Amendment No. 1”) to Service Agreement dated 26 September 2019 (the “Employment Agreement”) is entered into by the following Parties: BicycleTX Limited (the “Company”) and Nigel Crockett (“you”) (collectively the “Parties”), to provide clarity and define new terms agreed to by the Parties.

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